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Dosage and Administration

The dosage and duration of therapy of Lorazepam Injection USP must be individualized and carefully titrated in order to avoid excessive sedation or mental and motor impairment. The patients should not swallow for at least 2 minutes to allow sufficient time for absorption.
Excessive Anxiety Prior to Surgical Procedures:
Adults should take 0.05 mg/kg to a maximum of 4 mg, given by the sublingual route 1 to 2 hours before surgery. As with all premedicantdrugs, the dose should be individualized. Doses of other central nervous system depressant drugs should be ordinarily reduced.
Generalized Anxiety Disorder:
Initial adult daily oral dosage is 2 mg in divided doses of 0.5, 0.5 and 1 mg, or of 1 mg and 1 mg. The daily dosage should be carefully added or reduced by 0.5 mg depending upon tolerance and response. The usual daily dosage is 2 to 3 mg. However, the optimal dosage may range from 1 to 4 mg daily in individual patients. Usually, a daily dosage of 6 mg should not be exceeded. In elderly and debilitated patients, the initial daily dose should not exceed 0.5 mg and should be very carefully and gradually adjusted, depending upon tolerance and response.
Lorazepam Injection USP is compatible for dilution purposes with the following solutions: 0.9% Sodium Chloride Injection, USP 5% Dextrose Injection, USPThe sublingual tablet, when placed under the tongue, will dissolve in approximately 20 seconds.
Directions for Dilution
Aspirate the desired amount of Lorazepam Injection USP into the syringe, then slowly aspirate the desired volume of diluent. Pull back slightly on the plunger to provide additional mixing space. Immediately mix contents thoroughly by gently inverting the syringe repeatedly until a homogenous solution results. Do not shake vigorously since this will result in air entrapment.


Ativan (lorazepam) is contraindicated in patients with
– hypersensitivity to benzodiazepines or to any components of the formulation.
– acute narrow-angle glaucoma.

ATIVAN (lorazepam) Injection is contraindicated in patients with a known sensitivity to benzodiazepines or its vehicle (polyethylene glycol, propylene glycol, and benzyl alcohol), in patients with acute narrow-angle glaucoma, or in patients with sleep apnea syndrome. It is also contraindicated in patients with severe respiratory insufficiency, except in those patients requiring relief of anxiety and/or diminished recall of events while being mechanically ventilated. The use of ATIVAN Injectionintra-arterially is contraindicated because, as with other injectable benzodiazepines, an inadvertent intra-arterial injection may produce artery spasm resulting in gangrene which may require amputation

Side Effects

Ativan common side effects:
Sleep problems (insomnia)
Loss of balance or coordination
Forgetfulness or amnesia
Difficulty concentrating
Loss of balance or coordination
Muscle weakness
Blurred vision
Sleep problems (insomnia)
Loss of balance or coordination
Forgetfulness or amnesia
Difficulty concentrating
Changes in appetite
Skin rash

Associated use of benzodiazepines, including Ativan, and opioids may answer in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. As with all patients on CNS-depressant drugs, patients receiving lorazepam are warned not to operate dangerous machinery or motor vehicles and that their tolerance for alcohol and other CNS depressants will be diminished.For the treatment of status epilepticus, the usual recommended dose of ATIVAN
Injection is 4 mg given slowly (2 mg/min) for patients 18 years and older. If seizurescease, no additional ATIVAN Injection is required. If seizures continue or recur after a 10- to 15- minute observation period, an additional 4 mg intravenous dose may be slowly administered. Experience with further doses of ATIVAN is very limited. The usual precautions in treating status epilepticus should be employed. An intravenous infusion should be started, vital signs should be monitored, an unobstructed airway should be maintained, and artificial ventilation equipment should be available.Buy Ativan Online reviews
Respiratory Depression
The most important risk associated with the use of ATIVAN Injection in status epilepticus is respiratory depression. Accordingly, airway patency must be assured and respiration monitored closely. Ventilatory support should be given as required.
Excessive Sedation
Because of its prolonged duration of action, the prescriber should be alert to the possibility, especially when multiple doses have been given, that the sedative effects of lorazepam may add to the impairment of consciousness seen in the post-ictal state. For more info  WIKI

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