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Dosage and Administration
People who use MDMA usually take it as a capsule or tablet, though some swallow it in liquid form or snort the powder.it is common for Ecstasy to be combined with any of the following substances: Ecstasy, Caffeine, MDA, Methamphetamine, DXM, MDE, Pseudo/Ephedrine, Ketamine, BZP, and TFMPP. The typical dosage range of MDMA for recreational use varies from 50 mg to 150 mg, but the amount per tablet in different batches of tablets may vary 70-fold or more, from almost zero to well over 100 mg. The total amount consumed per occasion varies greatly among users. MDMA has been used primarily as a party drug rather than by solitary users Its current popularity arises from its use at “raves,” the all-night dance parties at which it is taken to postpone fatigue and allow the user to dance energetically for hours on end. For this purpose, the most common dosage has been 1–2 tablets during the course of the party but occasional case reports have indicated doses as high as 10 tablets in combination with other drugs
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MDMA can have many of the same physical effects as other stimulants
like cocaine and amphetamines. These include:
Lack of appetite,
Racing heartbeat and Convulsions
Anxiety, Feeling cold,
Jaw clenching/tight jaw,
Thirst, Restless legs,
Perceptual changes such as visual and auditory hallucinations,
Out-of-character irrational behavior, Irritability,
paranoia and aggression
High body temperature,
A person may experience the intoxicating effects of MDMA within 45
minutes or so after taking a single dose. Those effects include an
enhanced sense of well-being increased extroversion,
emotional warmth, empathy toward others, and a willingness to
discuss emotionally-charged memories. In addition, people report
enhanced sensory perception as a hallmark of the MDMA
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How Does MDMA Affect the Brain?
MDMA acts by increasing the activity of three neurotransmitters, serotonin, dopamine, and norepinephrine. The emotional and pro-social effects of MDMA are likely caused directly or indirectly by the release of large amounts of serotonin, which influences mood (as well as other functions such as appetite and sleep). Serotonin also triggers the release of the hormones oxytocin and vasopressin, which play important roles in love, trust, sexual arousal, and other social experiences. This may account for the characteristic feelings of emotional closeness and empathy produced by the drug; studies in both rats and humans have shown that MDMA raises the levels of these hormones.
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Various studies have found that MDMA use is associated with risky sexual behaviors. For example, both males and females who use MDMA are more likely than alcohol-drinking controls to engage in risky sexual behaviors (e.g., without a condom). MDMA use within the past 6 months is associated with initiating sex before age 14 and having two or more partners in the past 2 months. In addition, people who use heavily report more sexual risk-taking than those who use it less often. People who use heavily are also more likely to have been tested for HIV, though they believe they are at low risk for contracting the disease. Homosexuals and bisexuals who use MDMA, both male and female, reported more sexual partners and more injection drug use but did not have higher rates of unprotected sex and needle sharing compared to heterosexuals who use MDMA More Info
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