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Methadone changes the way your brain and nervous system respond to pain so that you feel relief. Its effects are slower than those of other strong painkillers like morphine. Your doctor may prescribe methadone if you’re in a lot of pain from an injury, surgery, or long-term illness.
It also blocks the high from drugs like codeine, heroin, hydrocodone, morphine, and oxycodone. It can give a similar feeling and keep you from having withdrawal symptoms and cravings. You may hear this called replacement therapy.
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Methadone is dispensed primarily in oral forms, including tablets, powder, and liquid for the treatment of narcotics addiction. Single doses, which should not exceed 80 – 100 milligrams daily, can last anywhere from 24 to 36 hours depending on user characteristics (e.g., age, weight, level of addiction, and tolerance); the long-acting nature of the drug is a distinct advantage since it requires less frequent administration, limiting potential harmful effects.12 Tablet forms of the drug, sometimes called diskettes, contain approximately 40 milligrams of methadone and are often dissolved in water and ingested orally. There is also a white crystalline powder form available that is dissolved in water and swallowed. Finally, the liquid is sometimes used in treatment clinics; with this method dosages of methadone can be tightly controlled and adjusted to as small as one milligram, this allows patients to receive just the right amount of methadone needed to curb their withdrawal symptoms.13 Illicit methadone is sometimes administered through injection (injection is not a valid route of administration in treatment) directly into the bloodstream. This form subjects users to increased risks of a variety of diseases, including
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Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in DOLOPHINE. Methadone is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute bronchial asthma or hypercarbia. Methadone is contraindicated in any patient who has or is suspected of having paralytic ileus.
Misuse, Abuse, and Diversion of Opioids: Methadone is a mu-agonist opioid with an abuse liability similar to that of morphine and is a Schedule II controlled
substance. Methadone, like morphine and other opioids used for analgesia, has the potential for being abused and is
subject to criminal diversion.
Methadone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered
when prescribing or dispensing DOLOPHINE in situations where the clinician is concerned about an increased risk
of misuse, abuse, or diversion.
Concerns about abuse, addiction, and diversion should not prevent the proper management of pain.
Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances
Authority for information on how to prevent and detect abuse or diversion of this product. Visit Wiki
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