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ULTRAM should not be administered to patients who have previously demonstrated hypersensitivity to tramadol, any other component of this product or opioids. ULTRAM is contraindicated in any situation where opioids are contraindicated, including acute intoxication with any of the following: alcohol, hypnotics, narcotics, centrally acting analgesics, opioids or psychotropic drugs. ULTR AM® may worsen central nervous system and respiratory depression in these patients.




Do not take Tramadol at the same time as medicines called “monoamine oxidase inhibitors” or MAOIs (which are used to treat e.g. depression), or if you have taken MAOIs in the past 2 weeks. The pain-relieving effect of Tramadol may be weakened and/or shortened if you also take medicines containing:
– carbamazepine (used to treat epilepsy)
– pentazocine, nalbuphine or buprenorphine (pain killers)
– ondansetron (used to stop you feeling sick).
Talk to your doctor or pharmacist before
taking Tramadol
– if you suffer from epilepsy or seizures (fits) or have had them in the past
because tramadol could increase the risk of you having further fits – if you have liver or kidney problems.
As with all painkillers of this type (opioid analgesics), tramadol should be used with caution, and only under medical supervision in seriously ill patients including those with breathing difficulties, excessively low blood pressure (shock), decreased consciousness,serious head injury or brain diseases that may cause elevated pressure in the skull.
Tramadol is transformed in the liver by an enzyme. Some people have a variation of this enzyme and this can affect people in different ways. In some people, they may not get enough pain relief but other people are more likely to get serious side effects. If you notice any of the following side effects, you must stop taking this medicine and seek immediate medical advice: slow or shallow breathing, confusion, sleepiness, small pupils, feeling or being sick, constipation, lack of appetite.

Children and adolescents
Use in children with breathing problems Tramadol is not recommended in children with breathing problems, since the symptoms of tramadol toxicity may be worse in these children.
Other medicines and Tramadol
Tell your doctor or pharmacist if you are taking, have recently taken. for more information follow Info

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